Synovial fluid or cerebrospinal fluid analysis
synovial fluid aspirate or biopsy, or lumbar puncture for cerebrospinal fluid analysis
tests per year, UK, only if the immunoblot is negative but symptoms persist, after specialist discussion
“1.2.20 If the immunoblot test for Lyme disease is negative (regardless of the ELISA result) but symptoms persist, consider a discussion with or referral to a specialist, to: review whether further tests may be needed for suspected Lyme disease, for example, synovial fluid aspirate or biopsy, or lumbar puncture for cerebrospinal fluid analysis”
NICE NG95, Lyme disease, section 1.2 Diagnosis, 2018-04
- Kind of source
- Clinical guideline
- Read on
- 2026-11-06
- Daily check
- Quote found at the source on 2026-11-06
- What to know
- A specialist-led further test, not routine; NICE says the specialist should review whether further tests are needed.
Used in
Kept as evidence; no figure on the platform is computed from it yet.